Planitox

The science based toxicology company

Planitox is a Planning, Consulting and Information in Toxicology company. Founded in 1994, the company’s goal is to offer services within the diffrent Toxicology areas, with technical-scientific accuracy, quality and ethics, aiming human health’s and environment protection.

About us

It’s multidisciplinar team of highly qualified professionals includes pharmacists, biologists, physicians and nurses.

Currently, Planitox renders services for several private companies, the public sector, non-governmental institutions, the academic area and diffrent business associations.

Planitox’s commitments with it’s clients involves:

  • Providing services with updates cientific bases, grounded by ethics and quality
  • Having na excelent quality of service, always looking forward the client’s satisfaction
  • Providing services of excelent quality and within our clients’s deadlines
  • Providing a responsable and dedicated work team
  • Providing credibility in the corporate decisions within the public health theme
  • Providing technical basis for legal contentions
  • Periodically measuring the clients’s satisfaction by researchs, with the goal to always improve the Client-Planitox relationship.

Mission

“Our missioon is to meet and overcome our clients’s expecations by offering excelent Toxicology services with unique quality, achieved by a constant updated and highly qualified team of people and acting with social reponsability, generating value for our clientes, business partners, employees and society”

Vision

“Our vision it to be recognized as a company of excellence in the brazilian and international market by offering outstanding services and technical capacity in the Toxicology area for the whole society, and keep expanding our actions with the commitment of continuosly improve our services and have a suistenable development of our company” .

Values

  • Respect our clients
  • Excellency and Quality
  • Reliability
  • Ethics
  • Team work
  • Value all our employees

Quality Policy

Planitox has obtained the ISO 9001:2008 certification in all services provided through BUREAU VERITAS Certification and is currently accredited by the Brazilian National Institute of Metrology (INMETRO).

Our Team

Planitox team is formed by over 35 qualified professionels, all trained to execute their Jobs with excellency.
Flávio A. D. Zambrone MD, PhD

Flávio A. D. Zambrone MD, PhD

Executive Director

  • MD (physician) at the University of Taubaté, with residence training in Nephrology.
  • Doctor degree in Medicine at the University of Campinas (UNICAMP)
  • Specialist in Public Health at the University of Campinas (UNICAMP)
  • Specialist in Toxicology and Clinical Pharmacology at the University of Paris VII – Hospital Fernand Widal (France)
  • Member of the American Academy of Clinical Toxicology.
  • Member of the Board of Trustees of ILSI, as an academic scientist representative.
  • Vice-president of the Latin America Association of Toxicology (ALATOX).
  • Director of the Scientific Board of International Life Science Institute (ILSI) – Brazil.
Cristiana L. Correa, PhD

Cristiana L. Correa, PhD

Technical Director

  • BS in Pharmacy at the Pontifical Catholic University of Campinas
  • Master degree in Toxicological Analysis and Ph.D. in Toxicology at the University of São Paulo
  • Specialist in Analytical Toxicology at the University of Campinas (UNICAMP)
  • Specialist in Toxicological Risk Assessment at a Postgraduate Education in Toxicology Program at the Wageningen University (The Netherlands).
Camila Mattoso Gomes

Camila Mattoso Gomes

Product Safety Manager

  • BS in Pharmacy at the Paulista State University, UNESP
Cybelle C. Tomazin, MSc

Cybelle C. Tomazin, MSc

Planitox - Line Manager (Toxicological Emergencies)

  • Bachelor’s degree in Nursing at the University of Campinas, UNICAMP
  • Specialist in Occupational Health Nursing at the Paulista University, UNIP
  • Master degree in Public Health at the University of Campinas, UNICAMP
Giuliana Selmi, M.Sc.

Giuliana Selmi, M.Sc.

Special Projects Manager

  • BS in Pharmacy at the Pontifical Catholic University of Campinas (PUCCAMP)
  • Master degree in Public Health, Epidemiology area, at the University of Campinas, UNICAMP
Ligia M. S. do Amaral, M.Sc.

Ligia M. S. do Amaral, M.Sc.

Safety Assessment Manager

  • BS in Pharmacy at the Pontifical Catholic University of Campinas (PUCCAMP)
  • Master degree in Toxicology and Toxicological Analysis at the University of São Paulo (USP)
Márcia G. Chow

Márcia G. Chow

Administrative Manager

  • Bachelor’s degree in Statistics at University of Campinas, UNICAMP

Partners and Clients

IBTox

ibtox_logositeThe Brazilian Institute of Toxicology (IBTox) is a private institution, exclusively dedicated on training and capacitating profesionals in the different fileds of the Science of Toxicology.

The Institute was created in 2012 with the aim to answer the brazilian market demand on forming profesionals in Toxicology, due to the crescent need of knowlodge in this specific science at the business areas such as Food, Cosmetics, Pharmaceuticals, Agrochemicals, Chemicals and Household Products.

Clients

Over time PLANITOX created a client’s list with many of the biggest and most important companies in the business areas of Food, Cosmetics, Pharmaceuticals, Agrochemicals, Chemicals and household Products, among others. Due to confidenciality reasons our clients’s names will be preserved.

Our Services

Safety Assessment

Toxicological Assessment

Toxicity assessment identifies adverse effects that a specific substance might exert on an organism by taking into consideration the different exposure routes.

Its main objective is to locate possible target-organs and the probable mechanisms through which the substance interacts with the organism and that might cause noxious effects to human health.

The conduction of the assessment process starts with the analysis of the substance physicochemical data, its structure-activity relation (SAR), epidemiological studies, studies with human volunteers, and toxicological and mechanicist studies with animals and other experimental models (in vivo and in vitro).

One of the purposes of toxicological assessment is to be included in the products registration process, such as pesticide registration processes (as determined by decree number 4.074/02 – Brazilian Legislation), besides being an essential document for the posterior elaboration of assessment of risk to human health.

Toxicity assessment can be done for the active ingredient or active principles of several types of products such as: pesticides, household products and cosmetics.

Risk Assessment

Risk assessment is a systematic process through which hazard, exposure, and risk are identified and quantified, and used as an important tool in the prevention of health and environmental hazard due to contact with, use and/or handling of chemical substances.

The risk assessment process is comprised of four fundamental steps: hazard identification; dose-response evaluation, exposure assessment, and risk characterization. The latter involves the calculation of an estimate of the incidence of adverse effects to health under various conditions of human exposure.

The assessment objectives include: the analysis of the relation between risk and benefit, establishment of targets and levels of risk, and assistance to determine activity priorities for the control and vigilance programs that are performed by regulatory agencies, industries, environmental and consumer organizations.

With over 20 years of experience, Planitox is highly prepared to realize risk assessments of various types of products, such as: agrochemicals, household products, industrial chemicals, dietary supplements among others.

Crisis management

Having in mind the definition of crisis as a rupture that physically affects the system as a whole and threatens basic suppositions and its existential core, and the value of management of these circumstances, which occur in a sudden and uncertain way, Planitox offers guidance and services to assist the companies in minimizing risks through strategies aimed at their recovery or at the visualization of alternatives to solve problems.

Technical report

Technical reports are scientific documents that are related to the different toxicology areas, including occupational, environmental, social, food, or medication, whose purpose is regulatory or legal, informative or elucidating.

Planitox is able to produce technical reports in all Toxicology’s areas.

Technical Surveillance

Attending and counseling at lawsuits by providing technical assistance to acquire toxicological information about the products, besides indicating experts specialized in specific subjects, and guidance about procedures and arguments made necessary for the defense or the prosecution.

Assistance in carrying out studies

Our team can give assistance to plan and to carry out exposure studies, toxicological studies and other projects focused on the principles of Good Laboratory Practices (GLP), besides scrutinizing reports related to these studies. These principles summarize a system of quality concerning the organizational process and the conditions in which these studies are planned, conducted, monitored, recorded, filed and reported.

As such, the audit service determines the degree of conformity with the national and international requirements (OECD Protocols – Organisation for Economic Co-operation and Development, InMetro Norms, among others) and verifies the integrity of the results, which guarantees that the quality of the resulting data complies with the assessment process, as well as with the determination/ requirements of the authorities.

To this effect, the following steps are followed and evaluated:

  • Planning – Study plan;
  • Conduction – Master agenda and Standard Operation Procedures (SOP);
  • Monitoring – Quality inspections;
  • Records – Logbooks and chain of custody;
  • Archives – Documents and specimens;
  • Report – Final report.

Planitox - Line (Toxicological Emergencies)

Vigilance Programs
A set of designated actions to study, identify and assess adverse effects caused by personal hygiene products, drugs, cosmetics and/or perfumes ruled by National Health Surveillance Agency (Agência Nacional de Vigilância Sanitária- ANVISA), Resolution – RDC N. 332 of December 1st, 2005.

To this effect, the following services are rendered:

  • Guidance, reference for treatment and follow up of cases by specialized physicians;
  • Notification of the contracting company within 24h;
  • Elaboration of an annual report to ANVISA.

24h Medical toxicological assistance service – Planitox Line®

Twenty-four-hour toxicological emergency service, toll-free phone assistance, that helps laypeople, health professionals, and other professionals with cases of intoxications or accidents provoked by cosmetics, pesticides, medications, industrial, household products, and foods.

Assistance is given in Portuguese, English and Spanish.

Main objectives:

  • To guide, refer for treatment, treat and prevent accidents and/or intoxications.
  • To follow-up the process of full recovery of the individual until health is restored.

The service has been acting in the market for 10 years with a multidisciplinary team and its proposition benefits industries and their brands, besides maintaining the well-being of their customers.

Product Safety

Label and printed directions for the use of chemical products

Elaboration and revision of labels and printed directions for the use of chemical products must follow legislation that is specific for each type of product (pesticides, medication, cosmetics, and household products).

On the label, a summary of the toxicological information concerning human health care is prepared, emphasizing:

  • First-aid;
  • antidotes;
  • Treatment in the case of emergency.

The printed directions for the use of chemical products must contain, besides the information on the label, data regarding:

  • the mechanism of action, absorption and excretion in laboratory animals or in humans, when available;
  • alarm symptoms;
  • acute and chronic effects in laboratory animals or in humans, when available;
  • known adverse effects.

Planitox is able to rigorous develop, review, adequate or translate labels and printed directions for the use of chemical products.

Emergency sheet – ES: Elaboration and revision

The emergency sheet is a document that accompanies the shipment of the product and summarizes the main risks and essential measures to be taken in the case of an accident.

It is elaborated according to criteria established by the National Agency of Terrestrial Transportation [Agência Nacional de Transportes Terrestres] resolution n. 420 as of 2004 and norms established by the Brazilian Association of Technical Norms [Associação Brasileira de Normas Técnicas], according to NBR 7503 as of 2004.

Planitox is able to rigorous develop, review, adequate or translate Emergency Sheets.

Material Safety Data Sheet– MSDS: Elaboration and revision

This document is normalized by the Brazilian Association of Technical Norms according to NBR 14725 as of 2001. The MSDS is designed to guide the users in handling chemical products.

It contains information about several aspects of substances or preparations concerning protection, safety, health, and environment, and provides basic knowledge about chemical products, recommendations on protection measures and actions to be taken in emergency situations.

It is divided in the following sections:

1) Identification of the product and company;

2) Composition and information about the ingredients;

3) Hazards identification;

4) First-aid measures;

5) Fire-fighting measures;

6) Spillage or leakage control measures;

7) Handling and storage;

8) Exposure control and individual protection;

9) Physicochemical properties;

10) Stability and reactivity;

11) Toxicological information;

12) Ecological information;

13) Considerations on treatment and disposal;

14) Shipping information;

15) Regulations;

16) Other information.

Planitox is able to rigorous develop, review, adequate or translate Material Safety Data Sheets.

Special Projects

Occupational monitoring

Occupational monitoring proposes mainly the accompaniment of employees during their daily work with the objective of measuring exposure to a specific chemical substance and assess the risk to which they are exposed, and subsequently implement corrective measures, whenever they are necessary.

Planitox provides advisory services for the development of field studies, through planning, follow-up, and interpretation of biological monitoring and passive dosimetry studies; performs surveillance audits of the tolerable limits found in the working ambience, and proposes intoxication control and prevention measures; acts together with the medical department assessing periodical exams and suggesting the need for other exams, based on the effective Brazilian Legislation and international agencies and organs protocols.

Since the main objective of occupational toxicology is to prevent alterations of the health of the worker exposed to chemical substances, the monitoring is extremely necessary, once it is defined as a systematic, continuous or repetitive activity related to health and developed to implement corrective measures, whenever they are needed.

Crisis management

Crisis Management

Having in mind the definition of crisis as a rupture that physically affects the system as a whole and threatens basic suppositions and its existential core, and the value of management of these circumstances, which occur in a sudden and uncertain way, Planitox offers guidance and services to assist the companies in minimizing risks through strategies aimed at their recovery or at the visualization of alternatives to solve problems.

Technical Surveillance

Attending and counseling at lawsuits by providing technical assistance to acquire toxicological information about the products, besides indicating experts specialized in specific subjects, and guidance about procedures and arguments made necessary for the defense or the prosecution.